5-Amino-1MQ is a small-molecule research compound that selectively inhibits nicotinamide N-methyltransferase (NNMT), an enzyme involved in metabolic regulation. By blocking NNMT, it enhances flux through the NAD⁺ salvage pathway, supporting improved energy homeostasis, sirtuin activation, and investigations into epigenetic and redox mechanisms linked to cellular metabolism and aging processes.

This membrane-permeable compound is a valuable tool in preclinical metabolic and regenerative research. Studies in animal models have demonstrated its potential to influence body composition, glucose handling, and muscle function without altering food intake.

Key preclinical findings include:

•  In high-fat diet-fed mice, administration led to approximately 5% body weight reduction, ~35% decrease in abdominal fat, over 30% reduction in fat cell size, and ~30% lower cholesterol levels.

•  When combined with a low-fat diet in obese models, it promoted a shift toward lean-like body composition and induced favorable gut microbiome changes (increased beneficial Lactobacillus and reduced harmful Erysipelatoclostridium) beyond diet alone.

•  In aged mice, it improved grip strength by about 40% (greater than exercise alone), with combined exercise yielding around 60% gains and sustained endurance enhancements, highlighting its role in muscle health research.

Important Notice: 5-Amino-1MQ is intended strictly for in vitro and in vivo laboratory research purposes only. It is not approved for human consumption, diagnostic use, or therapeutic applications. All handling and use must comply with applicable research regulations and safety guidelines.

Note: This product is provided as a Lyophilized, research-grade powder and does not come in liquid form.

 Disclaimer

Research Use Only Disclaimer:

Products from Flawless BioLabs are strictly for laboratory and research use by qualified professionals. They are not pharmaceuticals, dietary supplements, agricultural products, or household items, and must not be mislabeled as such. These chemicals are not intended for human or veterinary use and are exempt from Title 21, Parts 100–740 of the CFR. The information provided is educational, has not been evaluated by the FDA and is not intended to diagnose, treat, cure, or prevent any health condition.

Intellectual Property & Patent Use Disclaimer:  Flawless BioLabs provides this product solely for uses that fall under exemptions to patent infringement as permitted by applicable law, including but not limited to 35 U.S.C. § 271(e)(1) in the United States. It is the sole responsibility of the purchaser or user to ensure that their use of this product complies with all applicable intellectual property laws and legal exemptions. By purchasing this product, the buyer agrees to use it only within the scope of those exemptions and to indemnify and hold harmless Flawless BioLabs from any claims arising from its use, including any alleged intellectual property infringement.